Article
A Combination of M50I and V151I Polymorphic Mutations in HIV-1 Subtype B Integrase Results in Defects in Autoprocessing.
Viruses - 22 Nov 2021
Yang Jun, Hao Ming, Khan Muhammad A, Rehman Muhammad T, Highbarger Helene C, Chen Qian, Goswami Suranjana, Sherman Brad T, Rehm Catherine A, Dewar Robin L, Chang Weizhong, Imamichi Tomozumi
Abstract excerpt
We have recently reported that a recombinant HIV-1NL4.3 containing Met-to-Ile change at codon 50 of integrase (IN) (IN:M50I) exhibits suppression of the virus release below 0.5% of WT HIV, and the released viral particles are replication-incompetent due to defects in Gag/GagPol processing by inhibition of the initiation of autoprocessing of GagPol polyproteins in the virions and leads to replication-incompetent...
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