Article
A haplotype constituted of four MMP-2 promoter polymorphisms (-1575G/A, -1306C/T, -790T/G and -735C/T) is associated with coronary triple-vessel disease.
Matrix biology : journal of the International Society for Matrix Biology - 1 Jan 2004
Vasků Anna, Goldbergová Monika, Izakovicová Hollá Lydie, Sisková Lenka, Groch Ladislav, Beránek Michal, Tschöplová Svatava, Znojil Vladimír, Vácha Jirí
Abstract excerpt
Vascular lesion development is associated with an accumulation of extracellular matrix proteins within the vessel wall. The proteins are degraded by matrix metalloproteinases (MMPs). There is also evidence indicating a participation of the MMPs in the weakening of atherosclerotic plaque that predisposes to lesion disruption. The aim of the study was to test an association among haplotypes of four single...
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