Article
Tissue factor gene promoter haplotype associates with carotid intima-media thickness in subjects in cardiovascular risk prevention.
Atherosclerosis - 1 Nov 2009
Gertow Karl, Amato Mauro, Werba José Pablo, Bianchi Elena, Parolari Alessandro, Colnago Deborah, Brambilla Marta, Ravani Alessio, Veglia Fabrizio, Baldassarre Damiano, Camera Marina, Tremoli Elena
Abstract excerpt
OBJECTIVE: Tissue factor (TF), key initiator of coagulation, has been ascribed roles not only in thrombosis but also in atherosclerosis. TF gene promoter haplotypes modulate TF expression, thereby potentially affecting atherosclerosis. The objective of this study was to evaluate functionally relevant TF promoter haplotypes as determinants of carotid intima-media thickness (C-IMT), a marker of atherosclerosis....
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