Article

mTOR signaling controls the formation of smooth muscle cell-derived intimal fibroblasts during vasculitis

2023-12-15

Abstract excerpt

The excessive accumulation of fibroblasts within the intimal layer of inflamed vessels is a feared complication of vasculitis, which can lead to arterial stenosis and ischemia. In this study, we have investigated how such intimal fibroblasts develop during Kawasaki Disease (KD), a paediatric vasculitis typically involving the coronary arteries. By performing lineage tracing studies in a murine model of KD, we reve...

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Literature Corpus work: bf0362a8-f34b-56dc-a550-0e6389995dc9
DOI: 10.1101/2023.12.15.571811

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