Rat carotid neointimal smooth muscle cells reexpress a developmentally regulated mRNA phenotype during repair of arterial injury.

doi:10.1161/01.res.71.4.759

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Article

Rat carotid neointimal smooth muscle cells reexpress a developmentally regulated mRNA phenotype during repair of arterial injury.

Circulation research - 1 Oct 1992

Majesky M W, Giachelli C M, Reidy M A, Schwartz S M

Abstract excerpt

Smooth muscle cells (SMCs) cultured from the neointima of injured rat carotid arteries have a different shape and organization in vitro than SMCs from the uninjured media. The morphology of neointimal SMCs from adult rats strongly resembles that of a subset of medial SMCs from 12-day-old rat pups. In the present study, we show that adult carotid neointimal SMCs in vitro express the platelet-derived growth factor...

Topics

Age Factors
Animals
Animals, Newborn
Carotid Arteries
Carotid Artery Injuries
Cells, Cultured
Extracellular Matrix
Gene Expression
Male
Muscle, Smooth, Vascular
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Platelet-Derived Growth Factor

RNA, Messenger

Radioligand Assay

Rats

Rats, Inbred Strains

Time Factors

Tropoelastin

Source

Open in PubMed

Identifiers

PMID: 1516153
DOI: 10.1161/01.res.71.4.759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1516153-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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