Article
Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy.
Circulation - 16 Mar 2004
Tsybouleva Natalia, Zhang Lianfeng, Chen Suetnee, Patel Rajnikant, Lutucuta Silvia, Nemoto Shintaro, DeFreitas Gilberto, Entman Mark, Carabello Blase A, Roberts Robert, Marian A J
Abstract excerpt
BACKGROUND: Human hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young, is characterized by cardiac hypertrophy, myocyte disarray, and interstitial fibrosis. The genetic basis of HCM is largely known; however, the molecular mediators of cardiac phenotypes...
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