Model of the developing tumorigenic phenotype in mammalian cells and the roles of sustained stress and replicative senescence.

Abstract excerpt

The molecular mechanisms that drive mammalian cells to the development of cancer are the subject of intense biochemical, genetic and medical studies. But for the present, there is no comprehensive model that might serve as a general framework for the interpretation of experimental data. This paper is an attempt to create a conceptual model of the mechanism of the developing tumorigenic phenotype in mammalian...

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