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Article

Initiation of genetic instability and tumour formation: a review and hypothesis of a nongenotoxic mechanism.

Cellular and molecular life sciences : CMLS - 1 Jun 2003

Bignold L P

Abstract excerpt

Genetic instability in tumours results in cell-to-cell variability of genome which parallels the cell-to-cell variability of microscopic morphology and of behaviour (tumour cell heterogeneity) of these lesions. Genetic instability is therefore strongly supported as the fundamental process by which normal tissue cells become neoplastic. The commonest current suggestion for the mechanism of initiation of...

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Identifiers

PMID: 12861379
DOI: 10.1007/s00018-003-2314-6
PMCID: PMC11138812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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