Article
An oncogene-induced DNA damage model for cancer development.
Science (New York, N.Y.) - 7 Mar 2008
Halazonetis Thanos D, Gorgoulis Vassilis G, Bartek Jiri
Abstract excerpt
Of all types of DNA damage, DNA double-strand breaks (DSBs) pose the greatest challenge to cells. One might have, therefore, anticipated that a sizable number of DNA DSBs would be incompatible with cell proliferation. Yet recent experimental findings suggest that, in both precancerous lesions and cancers, activated oncogenes induce stalling and collapse of DNA replication forks, which in turn leads to formation...
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