Article
Combined effect of tumour necrosis factor-alpha and interleukin-13 polymorphisms on bronchial hyperresponsiveness in Korean children with asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 May 2008
Kim H-B, Kang M-J, Lee S-Y, Jin H-S, Kim J-H, Kim B-S, Jang S-O, Lee Y-C, Sohn M-H, Kim K-E, Hong S-J
Abstract excerpt
BACKGROUND: TNF-alpha and IL-13, two pivotal pro-inflammatory cytokines, are increased in asthmatic airways and may be linked to asthma susceptibility and/or bronchial hyperresponsiveness (BHR). OBJECTIVE: We investigated the association between the TNF-alpha-308G/A polymorphism and asthma susceptibility or asthma-related phenotypes in Korean children with asthma, and tested for a combined effect with IL-13...
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