A cell-based screen for function of the four-helix bundle protein Rop: a new tool for combinatorial experiments in biophysics.

Abstract excerpt

Combinatorial methodologies have revolutionized studies in biomolecular function, but they have so far proven less useful for understanding macromolecular structure and stability. This is largely because of the difficulty of screening libraries of molecules for biophysical properties, and the difficulty of interpreting structural effects in complicated molecules. Here, we report a novel, robust, cell-based screen...

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