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Article

Antifolate drug resistance: Novel mutations and haplotype distribution in dhps and dhfr from Northeast India.

Journal of biosciences - 1 Dec 2017

Sarmah N P, Sarma K, Bhattacharyya D R, Sultan A A, Bansal D, Singh N, Bharti P K, Sehgal R, Mohapatra P K, Parida P, Mahanta J

Abstract excerpt

Malaria is a major public health concern in Northeast India with a preponderance of drug-resistant strains. Until recently the partner drug for artemisinin combination therapy (ACT) was sulphadoxine pyrimethamine (SP). Antifolate drug resistance has been associated with the mutations at dihydropteroate synthase (dhps) and dihydrofolatereductase (dhfr) genes. This study investigated antifolate drug resistance at...

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PMID: 29229871
DOI: 10.1007/s12038-017-9706-5

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