Article
Antipneumococcal activity of ertapenem compared with gatifloxacin in a temperature-sensitive murine model of acute pneumonia.
Journal of chemotherapy (Florence, Italy) - 1 Aug 2007
De Azavedo J C S, Dresser L, Duncan C L, Walker S E, Low D E, Bast D J
Abstract excerpt
Fluoroquinolone-resistance among pneumococci is low; however the number of isolates with a single ParC mutation has increased. Consequently, more potent agents are needed to minimize resistance selection. We investigated the efficacy of ertapenem versus gatifloxacin in a temperature-sensitive mouse model of pneumonia caused by a wildtype Streptococcus pneumoniae strain (A66) and an isogenic mutant with a ParC...
Topics
- Animals
- Anti-Bacterial Agents
- DNA Topoisomerase IV
- Disease Models, Animal
- Ertapenem
- Fluoroquinolones
- Gatifloxacin
- Mice
- Mice, Inbred Strains
- Mutation
- Pneumonia, Pneumococcal