Article
Cyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancer.
Carcinogenesis - 1 Feb 2002
Wang Lizhong, Habuchi Tomonori, Takahashi Takeshi, Mitsumori Kenji, Kamoto Toshiyuki, Kakehi Yoshiyuki, Kakinuma Hideaki, Sato Kazunari, Nakamura Akira, Ogawa Osamu, Kato Tetsuro
Abstract excerpt
Cyclin D1 is believed to play an important role in the genesis and/or progression of transitional cell cancer (TCC) of the urinary bladder. Cyclin D1 gene (CCND1) mRNA is alternatively spliced to produce two transcripts, and the splicing pattern may be modulated by a G to A single nucleotide polymorphism within the splice donor site of exon 4. This study was conducted to explore the association between the...
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