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Article

Identification of rare polymerase variants of hepatitis B virus using a two-stage PCR with peptide nucleic acid clamping.

Journal of medical virology - 1 Apr 2004

Ohishi Waka, Shirakawa Hiroo, Kawakami Yoshiiku, Kimura Sonoko, Kamiyasu Masaya, Tazuma Susumu, Nakanishi Toshio, Chayama Kazuaki

Abstract excerpt

Emergence of lamivudine-resistant variants, with amino acid substitutions in the Tyr-Met-Asp-Asp (YMDD) motif of hepatitis B virus (HBV) reverse transcriptase, is a serious problem in antiviral therapy. Presence of YMDD motif variants in patients who had never been treated with lamivudine has been reported recently. However, no analysis of nucleotide and amino acid sequences of these variants has been performed....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14981758
DOI: 10.1002/jmv.20026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of rare polymerase variants of hepatitis B virus using a two-stage PCR with peptide nucleic acid clamping.PMID 14981758Read ↗

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