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Article

Rapid detection of lamivudine-resistant hepatitis B virus polymerase gene variants.

Journal of virological methods - 1 Dec 1999

Jardi R, Buti M, Rodriguez-Frias F, Cotrina M, Costa X, Pascual C, Esteban R, Guardia J

Abstract excerpt

The amino acid substitution from methionine to valine or isoleucine at the YMDD (tyrosine, methionine, aspartate, aspartate) motif of the HBV polymerase gene is the main mutation responsible for resistance to lamivudine treatment. Detection of emerging HBV variants by direct sequencing of the HBV genome is excessively time-consuming for studying large numbers of clinical samples. The aim of the study was to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10598095
DOI: 10.1016/s0166-0934(99)00125-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rapid detection of lamivudine-resistant hepatitis B virus polymerase gene variants.PMID 10598095Read ↗

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Quantification of the newly detected lamivudine resistant YSDD variants of Hepatitis B virus using molecular beacons.Semantic proximity Read ↗

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