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Article

The search for new sterilizing anti-tuberculosis drugs

1 Jan 2004

Abstract excerpt

To be of use in the control of tuberculosis, any new drug must be capable of shortening the duration of treatment by accelerating sterilizing activity, that is the rate at which Mycobacterium tuberculosis is killed in the lesions. The most difficult to kill are the extra-cellular bacilli in cavities. Persistence during therapy arises because there is a proportion of slowly metabolising bacilli (persisters) in the...

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PMID: 14977529
DOI: 10.2741/1293

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