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Article

Semiparametric variance components models for genetic studies with longitudinal phenotypes.

Biostatistics (Oxford, England) - 1 Jul 2012

Wang Yuanjia, Huang Chiahui

Abstract excerpt

In a family-based genetic study such as the Framingham Heart Study (FHS), longitudinal trait measurements are recorded on subjects collected from families. Observations on subjects from the same family are correlated due to shared genetic composition or environmental factors such as diet. The data have a 3-level structure with measurements nested in subjects and subjects nested in families. We propose a...

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Identifiers

PMID: 21933778
DOI: 10.1093/biostatistics/kxr027
PMCID: PMC3372943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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