Article
Genetic linkage analysis of longitudinal hypertension phenotypes using three summary measures.
BMC genetics - 31 Dec 2003
Rao Shaoqi, Li Lin, Li Xia, Moser Kathy L, Guo Zheng, Shen Gongqing, Cannata Ruth, Zirzow Erich, Topol Eric J, Wang Qing
Abstract excerpt
BACKGROUND: Longitudinal data often have multiple (repeated) measures recorded along a time trajectory. For example, the two cohorts from the Framingham Heart Study (GAW13 Problem 1) contain 21 and 5 repeated measures for hypertension phenotypes as well as epidemiological risk factors, respectively. Direct modelling of a large number of serially and biologically correlated traits in the context of linkage...
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