Article
HFE C282Y heterozygosity in hepatocellular carcinoma: evidence for an increased prevalence.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Jul 2003
Hellerbrand Claus, Pöppl Andreas, Hartmann Arndt, Schölmerich Jürgen, Lock Guntram
Abstract excerpt
BACKGROUND & AIMS: Iron overload is observed frequently in chronic liver disease, and some studies have suggested that chronic iron overload may contribute to the pathogenesis of hepatocellular carcinoma (HCC). Heterozygosity for hereditary hemochromatosis (HH) is associated with increased body iron stores. The discovery of the HH gene HFE has enabled identification of the heterozygote status. The aim of this...
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