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Article

Arabidopsis primary microRNA processing proteins HYL1 and DCL1 define a nuclear body distinct from the Cajal body.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2007

Song Liang, Han Meng-Hsuan, Lesicka Joanna, Fedoroff Nina

Abstract excerpt

Small regulatory microRNAs (miRNAs) are encoded in long precursors and are released from them during processing by cleavage within partially duplexed stem-loop structures. In the present work we investigated the role of the Arabidopsis nuclear RNA-binding protein HYL1 and the nuclear RNase III enzyme DCL1 in processing of primary miRNA (pri-miR171a). The miR171a gene is complex, with multiple transcription start...

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PMID: 17369351
DOI: 10.1073/pnas.0701061104
PMCID: PMC1838471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Arabidopsis primary microRNA processing proteins HYL1 and DCL1 define a nuclear body distinct from the Cajal body.PMID 17369351Read ↗

The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing.Semantic proximity Read ↗

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The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation.Semantic proximity Read ↗

The interaction between DCL1 and HYL1 is important for efficient and precise processing of pri-miRNA in plant microRNA biogenesis.Semantic proximity Read ↗

The helicase and RNaseIIIa domains of Arabidopsis Dicer-Like1 modulate catalytic parameters during microRNA biogenesis.Semantic proximity Read ↗

The N-terminal double-stranded RNA binding domains of Arabidopsis HYPONASTIC LEAVES1 are sufficient for pre-microRNA processing.Semantic proximity Read ↗

A dominant mutation in DCL1 suppresses the hyl1 mutant phenotype by promoting the processing of miRNA.Semantic proximity Read ↗

Intron Lariat RNA Inhibits MicroRNA Biogenesis by Sequestering the Dicing Complex in Arabidopsis.Semantic proximity Read ↗

Transcriptome analyses revealed diverse expression changes in ago1 and hyl1 Arabidopsis mutants.Semantic proximity Read ↗

Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesisSemantic proximity Read ↗

KETCH1 imports HYL1 to nucleus for miRNA biogenesis in Arabidopsis.Semantic proximity Read ↗

The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development.Semantic proximity Read ↗

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