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Article

The TP53-ARF tumor suppressor pathway is frequently disrupted in large/cell anaplastic medulloblastoma.

Brain research. Molecular brain research - 5 Feb 2004

Frank Adrian J, Hernan Roberto, Hollander Andrew, Lindsey Janet C, Lusher Meryl E, Fuller Christine E, Clifford Steven C, Gilbertson Richard J

Abstract excerpt

We analyzed the TP53 and INK4A/ARF loci in 29 pediatric medulloblastomas. Mutually exclusive mutation in TP53, methylation of P14(ARF) or deletion of INK4A/ARF were identified in 21% (6/29) of tumors. Five of these alterations were detected in large cell/anaplastic medulloblastomas or tumors with...

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Identifiers

PMID: 14969745
DOI: 10.1016/j.molbrainres.2003.11.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14969745-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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