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p16<sup>INK4A</sup>and p14<sup>ARF</sup>Tumor Suppressor Pathways Are Deregulated in Malignant Rhabdoid Tumors

10 Jun 2011

Abstract excerpt

Malignant rhabdoid tumors (MRTs) are aggressive tumors associated with mutations in the SMARCB1 gene. In experimental systems, the loss of SMARCB1 is hypothesized to alter p16(INK4A) pathways resulting in the repression of tumor suppressors. To determine whether these pathways are deregulated in human MRT, we used immunohistochemistry on tissue microarrays to evaluate p16(INK4A)/E2F1/RB and p14(ARF)/MDM2/p53...

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PMID: 21666498
DOI: 10.1097/nen.0b013e31822146ca

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