Article
Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells.
Neoplasia (New York, N.Y.) - 1 Jan 2000
Cavallo-Medved Dora, Dosescu Julie, Linebaugh Bruce E, Sameni Mansoureh, Rudy Debbie, Sloane Bonnie F
Abstract excerpt
Cathepsin B protein and activity are known to localize to the basal plasma membrane of colon carcinoma cells following the appearance of K-ras mutations. Using immunofluorescence and subcellular fractionation techniques and two human colon carcinoma cell lines - one with a mutated K-ras allele (HCT 116) and a daughter line in which the mutated allele has been disrupted (HKh-2)-we demonstrate that the localization...
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