Article
Contribution of disulfide bridging to epitope expression of the dengue type 2 virus envelope glycoprotein.
Journal of virology - 1 Mar 2004
Roehrig John T, Volpe Katharine E, Squires Jennifer, Hunt Ann R, Davis Brent S, Chang Gwong-Jen J
Abstract excerpt
The individual contributions of each of the six conserved disulfide (SS) bonds in the dengue 2 virus envelope (E) glycoprotein (strain 16681) to epitope expression was determined by measuring the reactivities of a panel of well-defined monoclonal antibodies (MAbs) with LLC-MK(2) cells that had been transiently transformed with plasmid vectors expressing E proteins that were mutant in their SS bonds. Three domain...
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