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Mutation analysis of the cross-reactive epitopes of Japanese encephalitis virus envelope glycoprotein

16 Feb 2012

Abstract excerpt

Group and serocomplex cross-reactive epitopes have been identified in the envelope (E) protein of several flaviviruses and have proven critical in vaccine and diagnostic antigen development. Here, we performed site-directed mutagenesis across the E gene of a recombinant expression plasmid that encodes the Japanese encephalitis virus (JEV) premembrane (prM) and E proteins and produces JEV virus-like particles...

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PMID: 22337639
DOI: 10.1099/vir.0.040238-0

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