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Article

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

The Journal of experimental medicine - 1 Jan 1994

Spina C A, Kwoh T J, Chowers M Y, Guatelli J C, Richman D D

Abstract excerpt

The viral regulatory gene, nef, is unique to the human immunodeficiency viruses (HIV) and their related primate lentiviruses. Expression of the nef gene has been shown to be essential to the maintenance of high levels of virus replication and the development of pathogenesis in the animal model of simian immunodeficiency virus (SIV) infection. In contrast to this in vivo model, the use of standard T cell culture...

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Identifiers

PMID: 7903679
DOI: 10.1084/jem.179.1.115
PMCID: PMC2191324

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.PMID 7903679Read ↗

Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T LymphocytesSemantic proximity Read ↗

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.Semantic proximity Read ↗

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.Semantic proximity Read ↗

Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1Semantic proximity Read ↗

Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase.Semantic proximity Read ↗

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1Semantic proximity Read ↗

Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entrySemantic proximity Read ↗

Nef Enhances Human Immunodeficiency Virus Replication and Responsiveness to Interleukin-2 in Human Lymphoid Tissue Ex VivoSemantic proximity Read ↗

Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1.Semantic proximity Read ↗

Primary Cell Model for Activation-Inducible Human Immunodeficiency VirusSemantic proximity Read ↗

The Nef protein of primate lentivirusesSemantic proximity Read ↗

Interactions of HIV-1 NEF with cellular signal transducing proteinsSemantic proximity Read ↗

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