Article
The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.
The Journal of experimental medicine - 1 Jan 1994
Spina C A, Kwoh T J, Chowers M Y, Guatelli J C, Richman D D
Abstract excerpt
The viral regulatory gene, nef, is unique to the human immunodeficiency viruses (HIV) and their related primate lentiviruses. Expression of the nef gene has been shown to be essential to the maintenance of high levels of virus replication and the development of pathogenesis in the animal model of...
Topics
- Base Sequence
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- DNA Primers
- Genes, nef
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Virus Replication