Article
The common variants/multiple disease hypothesis of common complex genetic disorders.
Medical hypotheses - 1 Jan 2004
Becker Kevin G
Abstract excerpt
Unlike simple rare Mendelian disorders, the genetic basis for common disorders is unclear. A general model of the genetics of common complex disorders is proposed which emphasizes the shared nature of common alleles in related common disorders, such as schizophrenia and bipolar disorder, Type II diabetes and obesity, and among autoimmune diseases. This model, the common variants/multiple disease hypothesis,...
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