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Article

Common vs. rare allele hypotheses for complex diseases.

Current opinion in genetics & development - 1 Jun 2009

Schork Nicholas J, Murray Sarah S, Frazer Kelly A, Topol Eric J

Abstract excerpt

There has been growing debate over the nature of the genetic contribution to individual susceptibility to common complex diseases such as diabetes, osteoporosis, and cancer. The 'Common Disease, Common Variant (CDCV)' hypothesis argues that genetic variations with appreciable frequency in the population at large, but relatively low 'penetrance' (or the probability that a carrier of the relevant variants will...

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Identifiers

PMID: 19481926
DOI: 10.1016/j.gde.2009.04.010
PMCID: PMC2914559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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