Article
Evaluation of the IRF-2 gene as a candidate for PSORS3.
The Journal of investigative dermatology - 1 Jan 2004
Foerster John, Nolte Ilja, Schweiger Susann, Ehlert Claudia, Bruinenberg Marcel, Spaar Katja, van der Steege Gerrit, Mulder Marcel, Kalscheuer Vera, Moser Bettina, Kijas Zofia, Seeman Petra, Ständer Markward, Sterry Wolfram, te Meerman Gerard
Abstract excerpt
Type 1 interferon can trigger flares of psoriasis. Hypersensitivity to type 1 interferon signaling causes a psoriasis-like skin disease in mice deficient for the transcription factor interferon regulatory factor 2 (IRF2). The human IRF2 gene is located at a previously identified candidate psoriasis susceptibility locus on chromosome 4q (PSORS3 at D4S1535). Therefore, we tested association of psoriasis with IRF2....
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