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Article

Determination of detection and quantification limits for SNP allele frequency estimation in DNA pools using real time PCR.

Nucleic acids research - 11 Feb 2004

Schwarz Gerhard, Bäumler Stefan, Block Annette, Felsenstein Friedrich G, Wenzel Gerhard

Abstract excerpt

The quantification of single nucleotide polymorphism (SNP) allele frequencies in pooled DNA samples using real time PCR is a promising approach for large-scale diagnostics and genotyping. The limits of detection (LOD) and limits of quantification (LOQ) for mutant SNP alleles are of particular imp...

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PMID: 14960708
DOI: 10.1093/nar/gnh020
PMCID: PMC373417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14960708-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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