Article
Similarity of spontaneous germinal and in vitro somatic cell mutation rates in humans: implications for carcinogenesis and for the role of exogenous factors in "spontaneous" germinal mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1992
Kuick R D, Neel J V, Strahler J R, Chu E H, Bargal R, Fox D A, Hanash S M
Abstract excerpt
The rate of spontaneous mutation resulting in electrophoretic variants per cell generation in a human lymphoblastoid cell line, on the basis of experiments described in this paper, is found to be 7.2 x 10(-8) per locus. A review of similar data on electrophoretic variants resulting from spontaneo...
Topics
- Alleles
- Animals
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Genetic Variation
- Hominidae
- Humans
- Mathematics
- Models, Genetic
- Mutagenesis