Article
Similarity of spontaneous germinal and in vitro somatic cell mutation rates in humans: implications for carcinogenesis and for the role of exogenous factors in "spontaneous" germinal mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1992
Kuick R D, Neel J V, Strahler J R, Chu E H, Bargal R, Fox D A, Hanash S M
Abstract excerpt
The rate of spontaneous mutation resulting in electrophoretic variants per cell generation in a human lymphoblastoid cell line, on the basis of experiments described in this paper, is found to be 7.2 x 10(-8) per locus. A review of similar data on electrophoretic variants resulting from spontaneous mutation in the human germ line leads to an estimate of 3.3 x 10(-8) per locus per cell generation. It is argued...
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