Spontaneous mutation as a risk factor.

Abstract excerpt

From various estimates of the mutation rate per nucleotide per generation, centering around 1-2 x 10(-8) and the number of nucleotide pairs, 3 x 10(9) per genome, the number of new mutations in a human zygote is very large, in the order of 100. The mutation rate is an order of magnitude higher in males than females, due presumably to the greater number of cell divisions in the male germ line, and increases more...

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