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Article

Biochemical and molecular basis of Glanzmann's thrombasthenia.

Haematologica - 1 Jan 2000

Perutelli P, Mori P G

Abstract excerpt

Glanzmann's thrombasthenia is a rare autosomal recessive bleeding disorder characterized by a quantitative deficiency or a functional abnormality of the major platelet membrane integrin receptor: the glycoprotein (GP) IIb/IIIa complex. The GPIIb/IIIa complex functions as a platelet receptor for fibrinogen, von Willebrand factor, fibronectin and vitronectin; therefore it plays an important role in platelet...

Topics

Chromosome Deletion
Female
Gene Expression Regulation
Genes, Recessive
Hemorrhagic Disorders
Humans
Male
Mutation
Platelet Adhesiveness
Platelet Aggregation
Platelet Membrane Glycoproteins
Thrombasthenia

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PMID: 1483593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1483593-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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