Article
Molecular basis of Glanzmann's Thrombasthenia and current strategies in treatment.
Blood reviews - 1 Sept 2002
Bellucci S, Caen J
Abstract excerpt
Glanzmann Thrombasthenia, an exceptional inherited platelet disorder is characterized by a complete lack of platelet aggregation due to a defect in the alpha(IIb)beta(3) complex or to a qualitative abnormality of this complex. Advances in molecular biology have permitted to precise the molecular abnormality on alpha(IIb) or beta(3) genes responsible for the disease and have also contributed to a better knowledge...
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