Article
Predictions of a 2-locus model for disease heterogeneity: application to adrenoleukodystrophy.
American journal of medical genetics - 15 Nov 1992
Maestri N E, Beaty T H
Abstract excerpt
Adrenoleukodystrophy (ALD) is an X-linked disorder that exhibits a wide range of phenotypic variability within individuals in a single family carrying the mutant allele. A 2-locus epistatic model has been proposed to explain the inheritance of the severe childhood form of ALD and the milder adult-onset adrenomyloneuropathy (AMN). Under a dominant epistatic model, a single M allele at an autosomal modifier locus...
Topics
- Adrenoleukodystrophy
- Crosses, Genetic
- Epistasis, Genetic
- Female
- Gene Frequency
- Genes, Dominant
- Genes, Recessive
- Genetic Markers
- Genetic Variation
- Humans
- Male
- Models, Genetic