Article
Germinal mosaicism and risk calculation in X-linked diseases.
American journal of human genetics - 1 May 1992
Jeanpierre M
Abstract excerpt
Germinal mosaicism is a major problem in risk estimation for an X-linked disease. A mutation can happen anytime in germ cell development, and the proportion of germ cells bearing the mutated gene is twice the probability of recurrence of the mutation. This proportion could be either very low in l...
Topics
- Data Interpretation, Statistical
- Female
- Gametogenesis
- Genetic Linkage
- Heterozygote
- Humans
- Male
- Mosaicism
- Mutation
- Pedigree
- Probability
- Risk
- Software
- X Chromosome