Article
Diallelic polymorphism may explain variations of the blood concentration of mannan-binding protein in Eskimos, but not in black Africans.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Dec 1992
Garred P, Madsen H O, Kurtzhals J A, Lamm L U, Thiel S, Hey A S, Svejgaard A
Abstract excerpt
Mannan-binding protein (MBP) is a lectin which, upon binding to certain carbohydrates, activates the classical pathway of complement without the involvement of antibody or C1q. Deficiency of the MBP is associated with an opsonic defect and recurrent infections during early life. An amino acid sub...
Topics
- Adolescent
- Adult
- Alleles
- Asian People
- Base Sequence
- Black People
- Carrier Proteins
- Collectins
- DNA
- Female
- Gene Frequency
- Genetic Variation
- Greenland
- Humans
- Immunologic Deficiency Syndromes
- Inuit
- Kenya
- Male