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Article

Diallelic polymorphism may explain variations of the blood concentration of mannan-binding protein in Eskimos, but not in black Africans.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Dec 1992

Garred P, Madsen H O, Kurtzhals J A, Lamm L U, Thiel S, Hey A S, Svejgaard A

Abstract excerpt

Mannan-binding protein (MBP) is a lectin which, upon binding to certain carbohydrates, activates the classical pathway of complement without the involvement of antibody or C1q. Deficiency of the MBP is associated with an opsonic defect and recurrent infections during early life. An amino acid substitution in the exon 1 at codon 54 in the MBP gene (GGC [glycine] to GAC [aspartic acid]) has been shown to be closely...

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Source

Identifiers

PMID: 1477092
DOI: 10.1111/j.1744-313x.1992.tb00083.x

Genes

MBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Diallelic polymorphism may explain variations of the blood concentration of mannan-binding protein in Eskimos, but not in black Africans.PMID 1477092Read ↗

A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein.Semantic proximity Read ↗

High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene.Semantic proximity Read ↗

Distinct and overlapping functions of allelic forms of human mannose binding protein.Semantic proximity Read ↗

Mannose-binding lectin (MBL) in health and disease.Semantic proximity Read ↗

DUAL ROLE OF MANNAN‐BINDING PROTEIN IN INFECTIONS: ANOTHER CASE OF HETEROSIS?Semantic proximity Read ↗

Distinct physicochemical characteristics of human mannose binding protein expressed by individuals of differing genotype.Semantic proximity Read ↗

Restricted polymorphism of the mannose-binding lectin gene of indigenous Australians.Semantic proximity Read ↗

Mutations in the human mannose-binding protein gene: frequencies in several population groups.Semantic proximity Read ↗

Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America.Semantic proximity Read ↗

Variants of the mannose-binding lectin gene in the Benin population: heterozygosity for the p.G57E allele may confer a selective advantage.Semantic proximity Read ↗

A dysfunctional allele of the mannose binding protein gene associates with systemic lupus erythematosus in a Spanish population.Semantic proximity Read ↗

A novel mannose-binding lectin-associated serine protease 1/3 gene variant.Semantic proximity Read ↗

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