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Article

Distinct and overlapping functions of allelic forms of human mannose binding protein.

Nature genetics - 1 Sept 1992

Super M, Gillies S D, Foley S, Sastry K, Schweinle J E, Silverman V J, Ezekowitz R A

Abstract excerpt

Human mannose binding protein (MBP) is a C-type serum lectin involved in first-line host defense against a variety of bacterial, fungal and viral pathogens. Recently an association was found between low levels of serum MBP and an increased frequency of recurrent infections in infants. A particular genotype, in which glycine is substituted by aspartic acid at codon 54 of MBP in the fifth collagen repeat, shows...

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Source

Identifiers

PMID: 1303250
DOI: 10.1038/ng0992-50

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Distinct and overlapping functions of allelic forms of human mannose binding protein.PMID 1303250Read ↗

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Dominant effects of mutations in the collagenous domain of mannose-binding protein.Semantic proximity Read ↗

Mannose-binding lectin: structure, function, genetics and disease associations.Semantic proximity Read ↗

Heteroligomeric forms of codon 54 mannose binding lectin (MBL) in circulation demonstrate reduced in vitro function.Semantic proximity Read ↗

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A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein.Semantic proximity Read ↗

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