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Article

Distinct and overlapping functions of allelic forms of human mannose binding protein.

Nature genetics - 1 Sept 1992

Super M, Gillies S D, Foley S, Sastry K, Schweinle J E, Silverman V J, Ezekowitz R A

Abstract excerpt

Human mannose binding protein (MBP) is a C-type serum lectin involved in first-line host defense against a variety of bacterial, fungal and viral pathogens. Recently an association was found between low levels of serum MBP and an increased frequency of recurrent infections in infants. A particular genotype, in which glycine is substituted by aspartic acid at codon 54 of MBP in the fifth collagen repeat, shows...

Topics

Alleles
Base Sequence
Carrier Proteins
Complement Pathway, Classical
DNA
Genotype
Humans
Infant
Infections
Mannose
Mannose-Binding Lectins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Structure

Opsonin Proteins

Phenotype

Point Mutation

Source

Identifiers

PMID: 1303250
DOI: 10.1038/ng0992-50

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1303250-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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