High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene.

doi:10.1093/hmg/1.9.709

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Article

High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene.

Human molecular genetics - 1 Dec 1992

Lipscombe R J, Sumiya M, Hill A V, Lau Y L, Levinsky R J, Summerfield J A, Turner M W

Abstract excerpt

We have previously identified, in three British families having an index child with frequent infections, a point mutation (GGC-->GAC) in codon 54 of exon 1 of the gene for the human lectin mannose binding protein (MBP). This was associated with low serum levels of this complement activating prote...

Topics

Adult
Asian People
Base Sequence
Black People
Carrier Proteins
Codon
DNA
Exons
Female
Gambia
Gene Frequency
Genotype
Heterozygote
Homozygote
Hong Kong
Humans
Infant, Newborn
Male

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