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Article

Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2004

Kam Yoonseok, Exton John H

Abstract excerpt

Mitogens activate protein translation through phosphorylation of p7S6 kinase (p70(S6K)) and eIF4E binding protein 1 (4E-BP1) mediated by the mammalian target of rapamycin (mTOR) or phosphoinositide 3-kinase (PI3K). A recent report (Science 294, 1942, 2001) has implicated phospholipase D (PLD) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14769825
DOI: 10.1096/fj.03-0731com

Genes

LPA
PLD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14769825-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid.PMID 14769825Read ↗

PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals.Semantic proximity Read ↗

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Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs).Semantic proximity Read ↗

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Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner.Semantic proximity Read ↗

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The activation of phospholipase D by endothelin-1, angiotensin II, and platelet-derived growth factor in vascular smooth muscle A10 cells is mediated by small G proteins of the ADP-ribosylation factor family.Semantic proximity Read ↗

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