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Article

Mutant p53 oncogene expression in keratoacanthoma and squamous cell carcinoma.

The British journal of dermatology - 1 Dec 1992

Stephenson T J, Royds J, Silcocks P B, Bleehen S S

Abstract excerpt

The tumour suppressor gene p53, located on the short arm of chromosome 17, encodes for a nuclear protein which regulates cell proliferation by inhibiting cells entering S-phase. p53 mutations are alleged to be the commonest genetic abnormality in human cancer. We studied mutant p53 oncoprotein expression, using PAb1801 monoclonal antibody immunohistochemistry, in 25 'ideal' keratoacanthomas and 26 well-, 19...

Topics

Carcinoma, Squamous Cell
Gene Expression
Genes, p53
Humans
Immunohistochemistry
Keratoacanthoma
Mutation
Skin Neoplasms
Tumor Suppressor Protein p53

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1476915
DOI: 10.1111/j.1365-2133.1992.tb14866.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1476915-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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