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Article

An EM algorithm for mapping binary disease loci: application to fibrosarcoma in a four-way cross mouse family.

Genetical research - 1 Oct 2003

Xu Shizhong, Yi Nengjun, Burke David, Galecki Andrzej, Miller Richard A

Abstract excerpt

Many diseases show dichotomous phenotypic variation but do not follow a simple Mendelian pattern of inheritance. Variances of these binary diseases are presumably controlled by multiple loci and environmental variants. A least-squares method has been developed for mapping such complex disease loci by treating the binary phenotypes (0 and 1) as if they were continuous. However, the least-squares method is not...

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PMID: 14768897
DOI: 10.1017/s0016672303006414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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