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Article

An EM algorithm for mapping binary disease loci: application to fibrosarcoma in a four-way cross mouse family.

Genetical research - 1 Oct 2003

Xu Shizhong, Yi Nengjun, Burke David, Galecki Andrzej, Miller Richard A

Abstract excerpt

Many diseases show dichotomous phenotypic variation but do not follow a simple Mendelian pattern of inheritance. Variances of these binary diseases are presumably controlled by multiple loci and environmental variants. A least-squares method has been developed for mapping such complex disease loc...

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PMID: 14768897
DOI: 10.1017/s0016672303006414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14768897-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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