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Article

BRASS: Permutation methods for binary traits in genetic association studies with structured samples.

PLoS genetics - 1 Nov 2023

Mbatchou Joelle, Abney Mark, McPeek Mary Sara

Abstract excerpt

In genetic association analysis of complex traits, permutation testing can be a valuable tool for assessing significance when the distribution of the test statistic is unknown or not well-approximated. This commonly arises, e.g, in tests of gene-set, pathway or genome-wide significance, or when the statistic is formed by machine learning or data adaptive methods. Existing applications include eQTL mapping,...

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PMID: 37934792
DOI: 10.1371/journal.pgen.1011020
PMCID: PMC10656004

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