Article
H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma.
Oncology reports - 1 Mar 2004
Shiratsuchi Hideki, Hirakawa Naoya, Saito Tsuyoshi, Oda Yoshinao, Yamamoto Hidetaka, Tomita Kichinobu, Yamamoto Tomoya, Tsuneyoshi Masazumi
Abstract excerpt
The conversion from a carcinomatous component to a sarcomatous one in spindle cell carcinoma (SPCC) of the upper aerodigestive tract is thought to occur via a series of molecular alterations; however the detailed mechanism is still unknown. We examined mutations at the H-ras and p53 genes in 16 SPCCs of upper aerodigestive tracts using PCR-RFLP, PCR-SSCP and direct sequencing analysis. The two distinct...
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