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Article

c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis.

Journal of cellular physiology - 1 Jul 2009

Vázquez Mary C, Vargas Lina M, Inestrosa Nibaldo C, Alvarez Alejandra R

Abstract excerpt

APP intracellular domain (AICD) has been proposed as a transcriptional inductor that moves to the nucleus with the adaptor protein Fe65 and regulates transcription. The two proteins, APP and Fe65, can be phosphorylated by c-Abl kinase. Neprilysin has been proposed as a target gene for AICD. We found that AICD expression is decreased by treatment with STI-571, a c-Abl inhibitor, suggesting a modulation of AICD...

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Source

Identifiers

PMID: 19306298
DOI: 10.1002/jcp.21743

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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