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Article

hFE65L influences amyloid precursor protein maturation and secretion.

Journal of neurochemistry - 1 Sept 1999

Guénette S Y, Chen J, Ferland A, Haass C, Capell A, Tanzi R E

Abstract excerpt

The amyloid precursor protein (APP) is processed in the secretory and endocytic pathways, where both the neuroprotective alpha-secretase-derived secreted APP (APPs alpha) and the Alzheimer's disease-associated beta-amyloid peptide are generated. All three members of the FE65 protein family bind the cytoplasmic domain of APP, which contains two sorting signals, YTS and YENPTY. We show here that binding of APP to...

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Source

Identifiers

PMID: 10461887
DOI: 10.1046/j.1471-4159.1999.0730985.x

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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