Article
Docking of endothelial nitric oxide synthase (eNOS) to the mitochondrial outer membrane: a pentabasic amino acid sequence in the autoinhibitory domain of eNOS targets a proteinase K-cleavable peptide on the cytoplasmic face of mitochondria.
The Journal of biological chemistry - 16 Apr 2004
Gao Shujuan, Chen Jun, Brodsky Sergey V, Huang Harer, Adler Stephen, Lee Juliane H, Dhadwal Neetu, Cohen-Gould Leona, Gross Steven S, Goligorsky Michael S
Abstract excerpt
Despite growing evidence for a mitochondrial localization of nitric oxide (NO) synthase and a broadening spectrum of NO actions on mitochondrial respiration and apoptosis, the basis for interaction between the enzyme and the organelle remain obscure. Here we investigated mitochondrial localization of endothelial nitric oxide synthase (eNOS) in human umbilical vein endothelial cells and human embryonic kidney...
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