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Article

Cysteine 184 of endothelial nitric oxide synthase is involved in heme coordination and catalytic activity.

The Journal of biological chemistry - 7 Oct 1994

Chen P F, Tsai A L, Wu K K

Abstract excerpt

Nitric oxide synthase catalyzes the formation of an important messenger molecule, nitric oxide (NO). It is a P450-type hemoprotein, containing a cysteine thiolate as its proximal heme ligand, but the exact cysteine residue involved in heme coordination has not been identified. To locate this specific cysteine, we altered three potential cysteine residues (Cys-99, Cys-184, and Cys-441) to alanine residues in human...

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PMID: 7523378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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