Cysteine 184 of endothelial nitric oxide synthase is involved in heme coordination and catalytic activity.

Article

Cysteine 184 of endothelial nitric oxide synthase is involved in heme coordination and catalytic activity.

The Journal of biological chemistry - 7 Oct 1994

Chen P F, Tsai A L, Wu K K

Abstract excerpt

Nitric oxide synthase catalyzes the formation of an important messenger molecule, nitric oxide (NO). It is a P450-type hemoprotein, containing a cysteine thiolate as its proximal heme ligand, but the exact cysteine residue involved in heme coordination has not been identified. To locate this spec...

Topics

Amino Acid Oxidoreductases
Amino Acid Sequence
Base Sequence
Cysteine
Endothelium, Vascular
Heme
Humans
Ligands
Molecular Sequence Data
Mutation
Nitric Oxide Synthase

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