Article
[Transfection of TF-1 cell line with human bcl-2 proto-oncogene provides short-term survival in absence of GM-CSF without changing the phenotype].
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion - 1 Jan 2000
Alvarado-Moreno J A, Nieves-Ramírez M E, Cáceres-Cortés J R
Abstract excerpt
UNLABELLED: Apoptosis is a process genetically controlled. The produce of the bcl-2 gene, bcl-2, is an anti apoptotic protein that is linked to the external membrane of the mitochondria. OBJECTIVE: To explore the possibility that bcl-2 transfection could change phenotype, response to mitogenic factor, and cell morphology on the TF-1 parental cell line and the bcl-2 transfectant TB-1 or TF-1neo. METHODS: We look...
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